Analysis Note

ControlPositive Control: Human brain lysate, NGF treated PC12 cells.

Application

Research CategoryNeuroscience

Research Sub CategoryDevelopmental NeuroscienceNeurodegenerative Diseases

This Anti-TorsinA Antibody is validated for use in IP, WB, IC for the detection of TorsinA.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

General description

TorsinA can regulate the cellular trafficking of the dopamine transporter, as well as other polytopic membrane-bound proteins, including G protein-coupled receptors, transporters, and ion channels. TorsinA is found in the dopamine neurons that are lost in PD, and is a component of Lewy bodies. in addition, a genetic defect in TorsinA underlies Torsion dystonia, a disease characterized by painful muscle contractions that result in uncontrollable distortions.

Immunogen

Maltose binding protein fusion protein from human torsinA.

Legal Information

CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany

Physical form

Liquid. Contaings no preservative

Ascites

Specificity

TorsinA

Storage and Stability

Maintain at -20°C in undiluted aliquots for up to 12 months after date of receipt. Avoid repeated freeze/thaw cycles.

Target description

37kDa